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KMID : 0356919930260010169
Korean Journal of Anesthesiology
1993 Volume.26 No. 1 p.169 ~ p.173
Prolonged Neuromuscular Blockde Following Succinylcholine Administration in a Patient with Plasma Cholinestrase Variant
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Abstract
The authors experienced a case of plasma cholinesterase variant who received succinylcholine, atracurium and reversal with pyridostigmine, and showed prolonged neuromuscular blockade postoperatively, and was ventilated artificially until complete
recovery.
The patient and her two children later gave samples of blood. The patient's blood revealed very low plasma cholinesterase activity of 0.11 IU/L(normal range; 5~12IU/L) and dibucainenumber of 33. In consideration of her children's plasma
cholinesterase
activities and dibucaine numbers, we suggest that she has genetically abnormal plasma cholinesterase and probably her genotype is E1a E1s or E1s E1s.
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